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Synthesis of the spiroketal core of integramycin
A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The eff...
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| Auteur principal: | |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Beilstein-Institut
2013
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3869345/ https://ncbi.nlm.nih.gov/pubmed/24367411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.282 |
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