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Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome
Amyloid precursor protein (APP), encoded on Hsa21, functions as a cell adhesion molecule (CAM) in axonal growth cones (GCs) of the developing brain. We show here that axonal GCs of human fetal Down syndrome (DS) neurons (and of a DS mouse model) overexpress APP protein relative to euploid controls....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868833/ https://ncbi.nlm.nih.gov/pubmed/24036883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-232686 |
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