Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome

Amyloid precursor protein (APP), encoded on Hsa21, functions as a cell adhesion molecule (CAM) in axonal growth cones (GCs) of the developing brain. We show here that axonal GCs of human fetal Down syndrome (DS) neurons (and of a DS mouse model) overexpress APP protein relative to euploid controls....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sosa, Lucas J., Postma, Nienke L., Estrada-Bernal, Adriana, Hanna, M., Guo, R., Busciglio, Jorge, Pfenninger, Karl H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Federation of American Societies for Experimental Biology 2014
Gaiak:
Research Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868833/
https://ncbi.nlm.nih.gov/pubmed/24036883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-232686
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