Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates

The neutrophil enzyme myeloperoxidase (MPO) promotes oxidative stress in numerous inflammatory pathologies by producing hypohalous acids. Its inadvertent activity is a prime target for pharmacological control. Previously, salicylhydroxamic acid was reported to be a weak reversible inhibitor of MPO....

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Detalhes bibliográficos
Main Authors: Forbes, Louisa V., Sjögren, Tove, Auchère, Françoise, Jenkins, David W., Thong, Bob, Laughton, David, Hemsley, Paul, Pairaudeau, Garry, Turner, Rufus, Eriksson, Håkan, Unitt, John F., Kettle, Anthony J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868775/
https://ncbi.nlm.nih.gov/pubmed/24194519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507756
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