Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates

The neutrophil enzyme myeloperoxidase (MPO) promotes oxidative stress in numerous inflammatory pathologies by producing hypohalous acids. Its inadvertent activity is a prime target for pharmacological control. Previously, salicylhydroxamic acid was reported to be a weak reversible inhibitor of MPO....

詳細記述

保存先:
書誌詳細
主要な著者: Forbes, Louisa V., Sjögren, Tove, Auchère, Françoise, Jenkins, David W., Thong, Bob, Laughton, David, Hemsley, Paul, Pairaudeau, Garry, Turner, Rufus, Eriksson, Håkan, Unitt, John F., Kettle, Anthony J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2013
主題:
Enzymology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868775/
https://ncbi.nlm.nih.gov/pubmed/24194519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507756
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