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Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants
The human AAA ATPase p97 is a molecular chaperone essential in cellular proteostasis. Single amino acid substitutions in p97 have been linked to a clinical multiple-disorder condition known as inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia. How t...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868774/ https://ncbi.nlm.nih.gov/pubmed/24196964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488924 |
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