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Structural and Functional Deviations in Disease-Associated p97 Mutants

Missense mutations that occur at the interface between two functional domains in the AAA protein p97 lead to suboptimal performance in its enzymatic activity and impaired intracellular functions, causing human disorders such as inclusion body myopathy associated with Paget's disease of the bone...

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Detalhes bibliográficos
Publicado no:J Struct Biol
Main Authors: Tang, Wai Kwan, Xia, Di
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788498/
https://ncbi.nlm.nih.gov/pubmed/22579784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2012.04.024
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