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Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser(262) and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons
β-amyloid peptide accumulation, tau hyperphosphorylation, and synapse loss are characteristic neuropathological symptoms of Alzheimer’s disease (AD). Tau hyperphosphorylation is suggested to inhibit the association of tau with microtubules, making microtubules unstable and causing neurodegeneration....
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868614/ https://ncbi.nlm.nih.gov/pubmed/24367683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084615 |
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