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Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser(262) and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

β-amyloid peptide accumulation, tau hyperphosphorylation, and synapse loss are characteristic neuropathological symptoms of Alzheimer’s disease (AD). Tau hyperphosphorylation is suggested to inhibit the association of tau with microtubules, making microtubules unstable and causing neurodegeneration....

詳細記述

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書誌詳細
主要な著者: Qureshi, Hamid Y., Han, Dong, MacDonald, Ryen, Paudel, Hemant K.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868614/
https://ncbi.nlm.nih.gov/pubmed/24367683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084615
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