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Familial FTDP-17 Missense Mutations Inhibit Microtubule Assembly-promoting Activity of Tau by Increasing Phosphorylation at Ser(202) in Vitro

In Alzheimer disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and other tauopathies, tau accumulates and forms paired helical filaments (PHFs) in the brain. Tau isolated from PHFs is phosphorylated at a number of sites, migrates as ∼60-, 64-, and 68-kDa bands...

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Main Authors: Han, Dong, Qureshi, Hamid Y., Lu, Yifan, Paudel, Hemant K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679442/
https://ncbi.nlm.nih.gov/pubmed/19304664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901095200
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