Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser(262) and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

β-amyloid peptide accumulation, tau hyperphosphorylation, and synapse loss are characteristic neuropathological symptoms of Alzheimer’s disease (AD). Tau hyperphosphorylation is suggested to inhibit the association of tau with microtubules, making microtubules unstable and causing neurodegeneration....

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Autores principales: Qureshi, Hamid Y., Han, Dong, MacDonald, Ryen, Paudel, Hemant K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868614/
https://ncbi.nlm.nih.gov/pubmed/24367683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084615
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