The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis

Viral hepatitis, obesity, and alcoholism all represent major risk factors for hepatocellular carcinoma (HCC). Although these conditions also lead to integrated stress response (ISR) or unfolded protein response (UPR) activation, the extent to which these stress pathways influence the pathogenesis of...

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Main Authors: DeZwaan-McCabe, Diane, Riordan, Jesse D., Arensdorf, Angela M., Icardi, Michael S., Dupuy, Adam J., Rutkowski, D. Thomas
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868529/
https://ncbi.nlm.nih.gov/pubmed/24367269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003937
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