The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL

DAPK2 is a proapoptotic protein that is mostly expressed in the hematopoietic tissue. A detailed DAPK2 expression analysis in two large AML patient cohorts revealed particularly low DAPK2 mRNA levels in APL. DAPK2 levels were restored in APL patients undergoing ATRA therapy. PML-RARA is the predomin...

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Bibliographische Detailangaben
Hauptverfasser: Humbert, Magali, Federzoni, Elena A., Britschgi, Adrian, Schläfli, Anna M., Valk, Peter J. M., Kaufmann, Thomas, Haferlach, Torsten, Behre, Gerhard, Simon, Hans-Uwe, Torbett, Bruce E., Fey, Martin F., Tschan, Mario P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2014
Schlagworte:
Cell Development, Differentiation, & Trafficking
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868189/
https://ncbi.nlm.nih.gov/pubmed/24038216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1112608
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