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Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain.

Autoradiography of restriction digests of DNA labeled in early S phase indicates that replication of the amplified dihydrofolate reductase (DHFR) domain of methotrexate-resistant CHOC 400 cells initiates within a 6.1-kilobase pair (kb) EcoRI-doublet located on the 3' side of the DHFR gene. To locali...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Burhans, W C, Selegue, J E, Heintz, N H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386807/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3094015/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.20.7790
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