Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases

Studies in NOD mice have provided important insight into the genetics and pathogenesis of type 1 diabetes (T1D). Our goal was to further explore novel methods of genetic manipulation in this mouse model. We tested the feasibility of using zinc-finger nucleases (ZFNs) to knock out a gene directly in...

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Главные авторы: Chen, Yi-Guang, Forsberg, Matthew H., Khaja, Shamim, Ciecko, Ashley E., Hessner, Martin J., Geurts, Aron M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2014
Предметы:
Technological Advances
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868049/
https://ncbi.nlm.nih.gov/pubmed/23974926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0192
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