Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS) mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence suggests that des-AG (dAG) has biological activity through GHSR-independent mechanisms. We combined in vitro and in vivo approaches to test possi...

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Autors principals: Heppner, Kristy M., Piechowski, Carolin L., Müller, Anne, Ottaway, Nickki, Sisley, Stephanie, Smiley, David L., Habegger, Kirk M., Pfluger, Paul T., DiMarchi, Richard, Biebermann, Heike, Tschöp, Matthias H., Sandoval, Darleen A., Perez-Tilve, Diego
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2014
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868046/
https://ncbi.nlm.nih.gov/pubmed/24062249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0414
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