The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

The G protein-coupled receptor 83 (Gpr83) is widely expressed in brain regions regulating energy metabolism. Here we report that hypothalamic expression of Gpr83 is regulated in response to nutrient availability and is decreased in obese mice compared with lean mice. In the arcuate nucleus, Gpr83 co...

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Autors principals: Müller, Timo D., Müller, Anne, Yi, Chun-Xia, M Habegger, Kirk, Meyer, Carola W., Gaylinn, Bruce D., Finan, Brian, Heppner, Kristy, Trivedi, Chitrang, Bielohuby, Maximilian, Abplanalp, William, Meyer, Franziska, Piechowski, Carolin L., Pratzka, Juliane, Stemmer, Kerstin, Holland, Jenna, Hembree, Jazzmin, Bhardwaj, Nakul, Raver, Christine, Ottaway, Nickki, Krishna, Radha, Sah, Renu, Sallee, Floyd R., Woods, Stephen C., Perez-Tilve, Diego, Bidlingmaier, Martin, Thorner, Michael O., Krude, Heiko, Smiley, David, DiMarchi, Richard, Hofmann, Susanna, Pfluger, Paul T., Kleinau, Gunnar, Biebermann, Heike, Tschöp, Matthias H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709495/
https://ncbi.nlm.nih.gov/pubmed/23744028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2968
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