The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

The G protein-coupled receptor 83 (Gpr83) is widely expressed in brain regions regulating energy metabolism. Here we report that hypothalamic expression of Gpr83 is regulated in response to nutrient availability and is decreased in obese mice compared with lean mice. In the arcuate nucleus, Gpr83 co...

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Main Authors: Müller, Timo D., Müller, Anne, Yi, Chun-Xia, M Habegger, Kirk, Meyer, Carola W., Gaylinn, Bruce D., Finan, Brian, Heppner, Kristy, Trivedi, Chitrang, Bielohuby, Maximilian, Abplanalp, William, Meyer, Franziska, Piechowski, Carolin L., Pratzka, Juliane, Stemmer, Kerstin, Holland, Jenna, Hembree, Jazzmin, Bhardwaj, Nakul, Raver, Christine, Ottaway, Nickki, Krishna, Radha, Sah, Renu, Sallee, Floyd R., Woods, Stephen C., Perez-Tilve, Diego, Bidlingmaier, Martin, Thorner, Michael O., Krude, Heiko, Smiley, David, DiMarchi, Richard, Hofmann, Susanna, Pfluger, Paul T., Kleinau, Gunnar, Biebermann, Heike, Tschöp, Matthias H.
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709495/
https://ncbi.nlm.nih.gov/pubmed/23744028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2968
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