Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS) mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence suggests that des-AG (dAG) has biological activity through GHSR-independent mechanisms. We combined in vitro and in vivo approaches to test possi...

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Autori principali: Heppner, Kristy M., Piechowski, Carolin L., Müller, Anne, Ottaway, Nickki, Sisley, Stephanie, Smiley, David L., Habegger, Kirk M., Pfluger, Paul T., DiMarchi, Richard, Biebermann, Heike, Tschöp, Matthias H., Sandoval, Darleen A., Perez-Tilve, Diego
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2014
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868046/
https://ncbi.nlm.nih.gov/pubmed/24062249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0414
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