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Angiotensin converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4 deficient mice
Aortic aneurysms are life-threatening and often associated with defects in connective tissues and mutations in smooth muscle cell (SMC) contractile proteins. Despite recent advances in understanding altered signaling in aneurysms of Marfan syndrome, the underlying mechanisms and options for pharmaco...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3867808/ https://ncbi.nlm.nih.gov/pubmed/23636094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005025 |
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