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Differences in genetic signaling, and not mechanical properties of the wall, are linked to ascending aortic aneurysms in fibulin-4 knockout mice

Fibulin-4 is an extracellular matrix protein that is essential for proper assembly of arterial elastic fibers. Mutations in fibulin-4 cause cutis laxa with thoracic aortic aneurysms (TAAs). Sixty percent of TAAs occur in the ascending aorta (AA). Newborn mice lacking fibulin-4 (Fbln4(−/−)) have aneu...

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Detalles Bibliográficos
Publicado en:Am J Physiol Heart Circ Physiol
Main Authors: Kim, Jungsil, Procknow, Jesse D., Yanagisawa, Hiromi, Wagenseil, Jessica E.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491524/
https://ncbi.nlm.nih.gov/pubmed/25934097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00178.2015
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