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Abnormal mechanosensing and cofilin activation promotes the progression of ascending aortic aneurysms in mice
Smooth muscle cells (SMCs) and the extracellular matrix (ECM) are intimately associated in the aortic wall. Fbln4(SMKO) mice with a smooth muscle cell-specific deletion of the Fbln4 gene, which encodes the vascular ECM component fibulin-4, develop ascending aortic aneurysms that have increased abund...
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| Publié dans: | Sci Signal |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5572214/ https://ncbi.nlm.nih.gov/pubmed/26486174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab3141 |
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