Abnormal mechanosensing and cofilin activation promotes the progression of ascending aortic aneurysms in mice

Smooth muscle cells (SMCs) and the extracellular matrix (ECM) are intimately associated in the aortic wall. Fbln4(SMKO) mice with a smooth muscle cell-specific deletion of the Fbln4 gene, which encodes the vascular ECM component fibulin-4, develop ascending aortic aneurysms that have increased abund...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Yamashiro, Yoshito, Papke, Christina L., Kim, Jungsil, Ringuette, Lea-Jeanne, Zhang, Qing-Jun, Liu, Zhi-Ping, Mirzaei, Hamid, Wagenseil, Jessica E., Davis, Elaine C., Yanagisawa, Hiromi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572214/
https://ncbi.nlm.nih.gov/pubmed/26486174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab3141
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