Abnormal mechanosensing and cofilin activation promotes the progression of ascending aortic aneurysms in mice

Smooth muscle cells (SMCs) and the extracellular matrix (ECM) are intimately associated in the aortic wall. Fbln4(SMKO) mice with a smooth muscle cell-specific deletion of the Fbln4 gene, which encodes the vascular ECM component fibulin-4, develop ascending aortic aneurysms that have increased abund...

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Bibliografische gegevens
Gepubliceerd in:Sci Signal
Hoofdauteurs: Yamashiro, Yoshito, Papke, Christina L., Kim, Jungsil, Ringuette, Lea-Jeanne, Zhang, Qing-Jun, Liu, Zhi-Ping, Mirzaei, Hamid, Wagenseil, Jessica E., Davis, Elaine C., Yanagisawa, Hiromi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572214/
https://ncbi.nlm.nih.gov/pubmed/26486174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab3141
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