Angiotensin converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4 deficient mice

Aortic aneurysms are life-threatening and often associated with defects in connective tissues and mutations in smooth muscle cell (SMC) contractile proteins. Despite recent advances in understanding altered signaling in aneurysms of Marfan syndrome, the underlying mechanisms and options for pharmaco...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Huang, Jianbin, Yamashiro, Yoshito, Papke, Christina L., Ikeda, Yuichi, Lin, Yanling, Patel, Miteshkumar, Inagami, Tadashi, Le, Victoria P., Wagenseil, Jessica E., Yanagisawa, Hiromi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867808/
https://ncbi.nlm.nih.gov/pubmed/23636094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005025
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