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Angiotensin converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4 deficient mice

Aortic aneurysms are life-threatening and often associated with defects in connective tissues and mutations in smooth muscle cell (SMC) contractile proteins. Despite recent advances in understanding altered signaling in aneurysms of Marfan syndrome, the underlying mechanisms and options for pharmaco...

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Bibliografiske detaljer
Main Authors: Huang, Jianbin, Yamashiro, Yoshito, Papke, Christina L., Ikeda, Yuichi, Lin, Yanling, Patel, Miteshkumar, Inagami, Tadashi, Le, Victoria P., Wagenseil, Jessica E., Yanagisawa, Hiromi
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867808/
https://ncbi.nlm.nih.gov/pubmed/23636094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005025
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