Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain

Hydroxamic acid-based histone deacetylase inhibitors (HDACis) are a class of molecules with therapeutic potential currently reflected in the use of suberoylanilide hydroxamic acid (SAHA; Vorinostat) to treat cutaneous T-cell lymphomas (CTCL). HDACis may have utility beyond cancer therapy, as preclin...

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Hlavní autoři: Wang, Changning, Eessalu, Thomas E, Barth, Vanessa N, Mitch, Charles H, Wagner, Florence F, Hong, Yijia, Neelamegam, Ramesh, Schroeder, Frederick A, Holson, Edward B, Haggarty, Stephen J, Hooker, Jacob M
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867727/
https://ncbi.nlm.nih.gov/pubmed/24380043
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