Isolation and Characterisation of Degradation Impurities in the Cefazolin Sodium Drug Substance

Two unknown impurities were detected in the cefazolin sodium bulk drug substance using gradient reversed-phase high-performance liquid chromategraphy (HPLC). These impurities were isolated by preparative HPLC and characterized by using spectroscopic techniques like LC-MS, LC-MS/MS, 1D, 2D NMR, and F...

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Autors principals: Sivakumar, Balasubramanian, Parthasarathy, Kannabiran, Murugan, Raman, Jeyasudha, Ramajeyabalan, Murugan, Saravanan, Saranghdar, Rajendira Janardhan
Format: Artigo
Idioma:Inglês
Publicat: Österreichische Apotheker-Verlagsgesellschaft 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867249/
https://ncbi.nlm.nih.gov/pubmed/24482765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3797/scipharm.1304-14
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