Islet-activating protein inhibits leukotriene D4- and leukotriene C4- but not bradykinin- or calcium ionophore-induced prostacyclin synthesis in bovine endothelial cells.

Incubation of the bovine endothelial cell line, CPAE, with leukotriene D4, leukotriene C4, bradykinin, or the calcium ionophore A23187 results in the release of arachidonic acid metabolites including 6-keto-prostaglandin F1 alpha, the stable metabolite of prostacyclin. Pretreatment of these cells wi...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Clark, M A, Conway, T M, Bennett, C F, Crooke, S T, Stadel, J M
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1986
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3094005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.19.7320
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