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Islet-activating protein inhibits leukotriene D4- and leukotriene C4- but not bradykinin- or calcium ionophore-induced prostacyclin synthesis in bovine endothelial cells.

Incubation of the bovine endothelial cell line, CPAE, with leukotriene D4, leukotriene C4, bradykinin, or the calcium ionophore A23187 results in the release of arachidonic acid metabolites including 6-keto-prostaglandin F1 alpha, the stable metabolite of prostacyclin. Pretreatment of these cells wi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Clark, M A, Conway, T M, Bennett, C F, Crooke, S T, Stadel, J M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3094005/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.19.7320
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