Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection

Ribonuclease L (RNase L) is a Type I Interferon regulated factor that can significantly inhibit retroviruses in vitro and may activate cytoplasmic sensing pathways to augment adaptive immunity. However, the antiretroviral activity of RNase L remains to be validated in vivo. We investigated the role...

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Main Authors: Li, Sam X., Barrett, Bradley S., Harper, Michael S., Heilman, Karl J., Halemano, Kalani, Steele, Amanda K., Guo, Kejun, Silverman, Robert H., Santiago, Mario L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866974/
https://ncbi.nlm.nih.gov/pubmed/23725696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.05.009
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