Modification of the Association Between Obesity and Lethal Prostate Cancer by TMPRSS2:ERG

BACKGROUND: TMPRSS2:ERG is a hormonally regulated gene fusion present in about half of prostate tumors. We investigated whether obesity, which deregulates several hormonal pathways, interacts with TMPRSS2:ERG to impact prostate cancer outcomes. METHODS: The study included 1243 participants in the pr...

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Autori principali: Pettersson, Andreas, Lis, Rosina T., Meisner, Allison, Flavin, Richard, Stack, Edward C., Fiorentino, Michelangelo, Finn, Stephen, Graff, Rebecca E., Penney, Kathryn L., Rider, Jennifer R., Nuttall, Elizabeth J., Martin, Neil E., Sesso, Howard D., Pollak, Michael, Stampfer, Meir J., Kantoff, Philip W., Giovannucci, Edward L., Loda, Massimo, Mucci, Lorelei A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866157/
https://ncbi.nlm.nih.gov/pubmed/24292212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djt332
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