Mast Cell Stabilization Decreases Cardiomyocyte and LV Function in Dogs with Isolated Mitral Regurgitation

BACKGROUND: Mast cells are increased in isolated mitral regurgitation (MR) in the dog and may mediate extracellular matrix (ECM) loss and left ventricular (LV) dilatation. We tested the hypothesis that mast cell stabilization would attenuate LV remodeling and improve function in the MR dog. METHODS:...

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Главные авторы: Pat, Betty, Killingsworth, Cheryl, Chen, Yuanwen, Gladden, James D, Walcott, Greg, Powell, Pamela, Denney, Thomas, Gupta, Himanshu, Desai, Ravi, Tillson, Michael, Dillon, A Ray, Dell’Italia, Louis J
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865763/
https://ncbi.nlm.nih.gov/pubmed/20797601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cardfail.2010.05.005
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