Mast Cell Stabilization Decreases Cardiomyocyte and LV Function in Dogs with Isolated Mitral Regurgitation

BACKGROUND: Mast cells are increased in isolated mitral regurgitation (MR) in the dog and may mediate extracellular matrix (ECM) loss and left ventricular (LV) dilatation. We tested the hypothesis that mast cell stabilization would attenuate LV remodeling and improve function in the MR dog. METHODS:...

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Hauptverfasser: Pat, Betty, Killingsworth, Cheryl, Chen, Yuanwen, Gladden, James D, Walcott, Greg, Powell, Pamela, Denney, Thomas, Gupta, Himanshu, Desai, Ravi, Tillson, Michael, Dillon, A Ray, Dell’Italia, Louis J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865763/
https://ncbi.nlm.nih.gov/pubmed/20797601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cardfail.2010.05.005
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