RNA recognition by human TLR8 can lead to autoimmune inflammation

Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its different function in human versus rodents. We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras were unable to pass germline; developed sever...

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Detalhes bibliográficos
Main Authors: Guiducci, Cristiana, Gong, Mei, Cepika, Alma-Martina, Xu, Zhaohui, Tripodo, Claudio, Bennett, Lynda, Crain, Chad, Quartier, Pierre, Cush, John J., Pascual, Virginia, Coffman, Robert L., Barrat, Franck J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865472/
https://ncbi.nlm.nih.gov/pubmed/24277153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131044
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