Characterization of mutations induced by 2-(N-acetoxy-N-acetyl)aminofluorene in the dihydrofolate reductase gene of cultured hamster cells.

To determine the types of alterations in gene structure that are induced by the carcinogen 2-(N-acetoxy-N-acetyl)aminofluorene, we used this compound to generate mutations at the dihydrofolate reductase (DHFR) locus (DHFR) in Chinese hamster ovary cells. Twenty-nine independent enzyme-deficient muta...

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Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Carothers, A M, Urlaub, G, Steigerwalt, R W, Chasin, L A, Grunberger, D
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 1986
Pynciau:	Research Article
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386535/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3018736/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.17.6519
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