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Characterization of mutations induced by 2-(N-acetoxy-N-acetyl)aminofluorene in the dihydrofolate reductase gene of cultured hamster cells.

To determine the types of alterations in gene structure that are induced by the carcinogen 2-(N-acetoxy-N-acetyl)aminofluorene, we used this compound to generate mutations at the dihydrofolate reductase (DHFR) locus (DHFR) in Chinese hamster ovary cells. Twenty-nine independent enzyme-deficient muta...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Carothers, A M, Urlaub, G, Steigerwalt, R W, Chasin, L A, Grunberger, D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386535/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3018736/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.17.6519
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