B Cell Responses to HIV Antigen Are a Potent Correlate of Viremia in HIV-1 Infection and Improve with PD-1 Blockade

Infection with Human Immunodeficiency Virus Type 1 (HIV-1) induces defects of both cellular and humoral immune responses. Impaired CD4+ T cell help and B cell dysfunction may partially explain the low frequency of broadly neutralizing antibodies in HIV-infected individuals. To understand the extent...

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Hauptverfasser: Nicholas, Katherine J., Zern, Emily K., Barnett, Louise, Smith, Rita M., Lorey, Shelly L., Copeland, Courtney A., Sadagopal, Shanmugalakshmi, Kalams, Spyros A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865293/
https://ncbi.nlm.nih.gov/pubmed/24358343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084185
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