Genetic variants and mutations of PPM1D control the response to DNA damage

The Wip1 phosphatase is an oncogene that is overexpressed in a variety of primary human cancers. We were interested in identifying genetic variants that could change Wip1 activity. We identified 3 missense SNPs of the human Wip1 phosphatase, L120F, P322Q, and I496V confer a dominant-negative phenoty...

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Hlavní autoři: Dudgeon, Crissy, Shreeram, Sathyavageeswaran, Tanoue, Kan, Mazur, Sharlyn J, Sayadi, Ahmed, Robinson, Robert C, Appella, Ettore, Bulavin, Dmitry V
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865055/
https://ncbi.nlm.nih.gov/pubmed/23907125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25694
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