Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4

Here, we developed a model system to evaluate the metabolic effects of oncogene(s) on the host microenvironment. A matched set of “normal” and oncogenically transformed epithelial cell lines were co-cultured with human fibroblasts, to determine the “bystander” effects of oncogenes on stromal cells....

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Bibliographic Details
Main Authors: Martinez-Outschoorn, Ubaldo E, Curry, Joseph M, Ko, Ying-Hui, Lin, Zhao, Tuluc, Madalina, Cognetti, David, Birbe, Ruth C, Pribitkin, Edmund, Bombonati, Alessandro, Pestell, Richard G, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865048/
https://ncbi.nlm.nih.gov/pubmed/23860378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25510
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