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Role of mu opioid receptor reserve and mu agonist efficacy as determinants of mu agonist effects on intracranial self-stimulation in rats

The net effect of mu opioid receptor agonists on intracranial self-stimulation (ICSS) in rats reflects an integration of rate-increasing and rate-decreasing effects. Prior opioid exposure is associated with tolerance to rate-decreasing effects and augmented expression of abuse-related rate-increasin...

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Hlavní autoři: Altarifi, Ahmad A., Miller, Laurence L., Negus, S. Stevens
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864003/
https://ncbi.nlm.nih.gov/pubmed/22914074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FBP.0b013e328358593c
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