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Role of mu opioid receptor reserve and mu agonist efficacy as determinants of mu agonist effects on intracranial self-stimulation in rats
The net effect of mu opioid receptor agonists on intracranial self-stimulation (ICSS) in rats reflects an integration of rate-increasing and rate-decreasing effects. Prior opioid exposure is associated with tolerance to rate-decreasing effects and augmented expression of abuse-related rate-increasin...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3864003/ https://ncbi.nlm.nih.gov/pubmed/22914074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FBP.0b013e328358593c |
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