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Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells.

Detergent-soluble DNA is the fraction (2-4%) of DNA that is released into the supernate upon mild detergent lysis. It is nonmitochondrial in origin. It labels efficiently with deoxy[3H]ribonucleosides and the labeling is prevented by inhibitors of polymerase alpha and ribonucleotide reductase. In pr...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhang, L H, Mui, S C, Todt, J C, Strauss, P R
Format: Artigo
Langue:Inglês
Publié: 1986
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC386398/
https://ncbi.nlm.nih.gov/pubmed/3016725
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