Structure and ubiquitination-dependent activation of Tank-Binding Kinase 1

Upon stimulation by pathogen-associated inflammatory signals, the atypical IκB kinase TBK1 induces type-I interferon expression and modulates NF-κB signaling. Here we describe the 2.4 Å-resolution crystal structure of nearly full-length TBK1 in complex with specific inhibitors. The structure reveals...

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Sonraí Bibleagrafaíochta
Main Authors: Tu, Daqi, Zhu, Zehua, Zhou, Alicia Y., Yun, Cai-hong, Lee, Kyung-Eun, Toms, Angela V., Li, Yiqun, Dunn, Gavin P., Chan, Edmond, Thai, Tran, Yang, Shenghong, Ficarro, Scott B., Marto, Jarrod A., Jeon, Hyesung, Hahn, William C., Barbie, David A., Eck, Michael J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863638/
https://ncbi.nlm.nih.gov/pubmed/23453972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.01.033
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