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Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.

To investigate the molecular mechanism for stereospecific binding of agonists to beta 2-adrenergic receptors we used receptor models to identify potential binding sites for the beta-OH-group of the ligand, which defines the chiral center. Ser-165, located in transmembrane helix IV, and Asn-293, situ...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wieland, K, Zuurmond, H M, Krasel, C, Ijzerman, A P, Lohse, M J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38632/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8799191/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.17.9276
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