Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.
To investigate the molecular mechanism for stereospecific binding of agonists to beta 2-adrenergic receptors we used receptor models to identify potential binding sites for the beta-OH-group of the ligand, which defines the chiral center. Ser-165, located in transmembrane helix IV, and Asn-293, situ...
Αποθηκεύτηκε σε:
| Εκδόθηκε σε: | Proc Natl Acad Sci U S A |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
1996
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8799191/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.17.9276 |
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