Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.

To investigate the molecular mechanism for stereospecific binding of agonists to beta 2-adrenergic receptors we used receptor models to identify potential binding sites for the beta-OH-group of the ligand, which defines the chiral center. Ser-165, located in transmembrane helix IV, and Asn-293, situ...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wieland, K, Zuurmond, H M, Krasel, C, Ijzerman, A P, Lohse, M J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8799191/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.17.9276
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