Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

The high aqueous solubility, poor permeability, and absorption of berberine (BBR) result in its low plasma level after oral administration, which greatly limits its clinical application. BBR solid lipid nanoparticles (SLNs) were prepared to achieve improved bioavailability and prolonged effect. Deve...

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Bibliografiske detaljer
Main Authors: Xue, Mei, Yang, Ming-xing, Zhang, Wei, Li, Xiu-min, Gao, De-hong, Ou, Zhi-min, Li, Zhi-peng, Liu, Su-huan, Li, Xue-jun, Yang, Shu-yu
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862509/
https://ncbi.nlm.nih.gov/pubmed/24353417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S51262
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