Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

The high aqueous solubility, poor permeability, and absorption of berberine (BBR) result in its low plasma level after oral administration, which greatly limits its clinical application. BBR solid lipid nanoparticles (SLNs) were prepared to achieve improved bioavailability and prolonged effect. Deve...

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Detalhes bibliográficos
Main Authors: Xue, Mei, Yang, Ming-xing, Zhang, Wei, Li, Xiu-min, Gao, De-hong, Ou, Zhi-min, Li, Zhi-peng, Liu, Su-huan, Li, Xue-jun, Yang, Shu-yu
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862509/
https://ncbi.nlm.nih.gov/pubmed/24353417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S51262
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