Large-scale Top-down Proteomics of the Human Proteome: Membrane Proteins, Mitochondria, and Senescence

Top-down proteomics is emerging as a viable method for the routine identification of hundreds to thousands of proteins. In this work we report the largest top-down study to date, with the identification of 1,220 proteins from the transformed human cell line H1299 at a false discovery rate of 1%. Mul...

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Bibliografiske detaljer
Main Authors: Catherman, Adam D., Durbin, Kenneth R., Ahlf, Dorothy R., Early, Bryan P., Fellers, Ryan T., Tran, John C., Thomas, Paul M., Kelleher, Neil L.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2013
Fag:
Special Issue: Post-translational Modifications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861700/
https://ncbi.nlm.nih.gov/pubmed/24023390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.030114
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