Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity

Autophagy can be activated via MTORC1 down-regulation by amino acid deprivation and by certain chemicals such as rapamycin, torin, and niclosamide. Lysosome is the degrading machine for autophagy but has also been linked to MTORC1 activation through the Rag/RRAG GTPase pathway. This association rais...

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Detalhes bibliográficos
Main Authors: Li, Min, Khambu, Bilon, Zhang, Hao, Kang, Jeong-Han, Chen, Xiaoyun, Chen, Daohong, Vollmer, Laura, Liu, Pei-Qing, Vogt, Andreas, Yin, Xiao-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861628/
https://ncbi.nlm.nih.gov/pubmed/24174532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.511212
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