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The NuRD Chromatin-Remodeling Enzyme CHD4 Promotes Embryonic Vascular Integrity by Transcriptionally Regulating Extracellular Matrix Proteolysis

The extracellular matrix (ECM) supports vascular integrity during embryonic development. Proteolytic degradation of ECM components is required for angiogenesis, but excessive ECM proteolysis causes blood vessel fragility and hemorrhage. Little is understood about how ECM proteolysis is transcription...

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Библиографические подробности
Главные авторы: Ingram, Kyle G., Curtis, Carol D., Silasi-Mansat, Robert, Lupu, Florea, Griffin, Courtney T.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861115/
https://ncbi.nlm.nih.gov/pubmed/24348274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004031
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