Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen

Non-muscle myosin II (MyoII) contractility is central to the regulation of numerous cellular processes, including migration. Rho is a well-characterized modulator of actomyosin contractility, but the function of other GTPases, such as Rac, in regulating contractility is currently not well understood...

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Autori principali: Jean, Léolène, Majumdar, Devi, Shi, Mingjian, Hinkle, Louis E., Diggins, Nicole L., Ao, Mingfang, Broussard, Joshua A., Evans, J. Corey, Choma, David P., Webb, Donna J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860307/
https://ncbi.nlm.nih.gov/pubmed/24144700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.131060
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