Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

Aberrant activation of the Hedgehog (Hh) pathway can drive tumorigenesis(1). To investigate the mechanism by which glioma-associated oncogene family zinc finger-1 (GLI1), a crucial effector of Hh signaling(2), regulates Hh pathway activation, we searched for GLI1-interacting proteins. We report that...

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Main Authors: Jagani, Zainab, Mora-Blanco, E Lorena, Sansam, Courtney G, McKenna, Elizabeth S, Wilson, Boris, Chen, Dongshu, Klekota, Justin, Tamayo, Pablo, Nguyen, Phuong T L, Tolstorukov, Michael, Park, Peter J, Cho, Yoon-Jae, Hsiao, Kathy, Buonamici, Silvia, Pomeroy, Scott L, Mesirov, Jill P, Ruffner, Heinz, Bouwmeester, Tewis, Luchansky, Sarah J, Murtie, Joshua, Kelleher, Joseph F, Warmuth, Markus, Sellers, William R, Roberts, Charles W M, Dorsch, Marion
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859448/
https://ncbi.nlm.nih.gov/pubmed/21076395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2251
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