PTEN Phosphatase-Independent Maintenance of Glandular Morphology in a Predictive Colorectal Cancer Model System

Organotypic models may provide mechanistic insight into colorectal cancer (CRC) morphology. Three-dimensional (3D) colorectal gland formation is regulated by phosphatase and tensin homologue deleted on chromosome 10 (PTEN) coupling of cell division cycle 42 (cdc42) to atypical protein kinase C (aPKC...

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Main Authors: Jagan, Ishaan C, Deevi, Ravi K, Fatehullah, Aliya, Topley, Rebecca, Eves, Joshua, Stevenson, Michael, Loughrey, Maurice, Arthur, Kenneth, Campbell, Frederick Charles
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press Inc. 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858899/
https://ncbi.nlm.nih.gov/pubmed/24348097
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