PTEN Phosphatase-Independent Maintenance of Glandular Morphology in a Predictive Colorectal Cancer Model System

Organotypic models may provide mechanistic insight into colorectal cancer (CRC) morphology. Three-dimensional (3D) colorectal gland formation is regulated by phosphatase and tensin homologue deleted on chromosome 10 (PTEN) coupling of cell division cycle 42 (cdc42) to atypical protein kinase C (aPKC...

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Autors principals: Ishaan C. Jagan, Ravi K. Deevi, Aliya Fatehullah, Rebecca Topley, Joshua Eves, Michael Stevenson, Maurice Loughrey, Kenneth Arthur, Frederick Charles Campbell
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2013-11-01
Col·lecció:Neoplasia: An International Journal for Oncology Research
Accés en línia:http://www.sciencedirect.com/science/article/pii/S1476558613800838
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