RESCUE OF GLANDULAR DYSMORPHOGENESIS IN PTEN-DEFICIENT COLORECTAL CANCER EPITHELIUM BY PPARγ-TARGETED THERAPY

Disruption of glandular architecture associates with poor clinical outcome in high grade colorectal cancer (CRC). PTEN regulates morphogenic growth of benign MDCK cells through effects on the Rho-like GTPase cdc42. This study investigates PTEN-dependent morphogenesis in a CRC model. Stable short hai...

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Detalhes bibliográficos
Main Authors: Jagan, Ishaan, Fatehullah, Aliya, Deevi, Ravi K, Bingham, Victoria, Campbell, Frederick Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446865/
https://ncbi.nlm.nih.gov/pubmed/22543585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.140
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